ID 110816
著者
チュウジョウ, ケイコ Kawashima Hospital
シマ, ケンジ Kawashima Hospital
タダ, ヒロアキ Kawashima Hospital
オオハシ, テルヨ Kawashima Hospital
ミナクチ, ジュン Kawashima Hospital
カワシマ, シュウ Kawashima Hospital
キーワード
glycohemoglobin
glycated albumin
hemodialysis
daily profile of blood glucose
life span of erythrocyte
資料タイプ
学術雑誌論文
抄録
Diabetics with end-stage renal disease (ESRD) exhibit abnormal life span of erythrocytes, and thus, HbAlc is not necessarily a good indicator for blood glucose control. The present study was conducted to reaffirm this point and determine whether glycated albumin (GA) can be used instead of HbAlc. The following three groups of patients with diabetes served as subjects : 49 predialysis patients with ESRD (predialysis group), 37 patients with ESRD on dialysis (dialysis group), and 40 patients without nephropathy (non-dialysis group). The profile set mean blood glucose was calculated by measuring blood glucose levels seven times a day. The relationship of profile set mean blood glucose with HbAlc and GA levels was then investigated. Corrected HbAlc levels were calculated by applying the profile set mean blood glucose of each ESRD patient to the regression formula for the HbAlc of non-dialysis patients. The actual and corrected HbAlc levels for the predialysis patients were 5.4±1.1 and 7.9±1.1%, respectively, while those for the dialysis patients were 5.6±1.0 and 7.5±0.9%, respectively (plt0.0001). The changes in GA levels in relation to the blood glucose control in the dialysis patients matched those in non-dialysis patients. HbAlc levels for diabetics with ESRD were lower than indicated by their blood glucose control. When assessing blood glucose control based solely on HbAlc, erroneous results may be obtained. In such cases, GA may be used instead of HbAlc.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
3-4
開始ページ
223
終了ページ
228
並び順
223
発行日
2006-08
フルテキストファイル
言語
eng
著者版フラグ
出版社版