ID 110839
Author
Honda, Junko Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
Sasa, Mitsunori Department of Surgery, Tokushima Breast Care Clinic
Moriya, Takuya Department of Pathology 2, Kawasaki Medical School
Bando, Yoshimi Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hirose, Toshiyuki Department of Surgery, National Higashi Tokushima Hospital
Takahashi, Masako Department of Surgery, Tokushima Breast Care Clinic
Nagao, Taeko Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
Tangoku, Akira Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
breast cancer
capecitabine
dihydropyrimidine dehydrogenase
predictive factor
thymidine phosphorylase
Content Type
Journal Article
Description
Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i.e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
55
Issue
1-2
Start Page
54
End Page
60
Sort Key
54
Published Date
2008-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences