ID 110839
著者
ホンダ, ジュンコ Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
ササ, ミツノリ Department of Surgery, Tokushima Breast Care Clinic
モリヤ, タクヤ Department of Pathology 2, Kawasaki Medical School
坂東, 良美 Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヒロセ, トシユキ Department of Surgery, National Higashi Tokushima Hospital
タカハシ, マサコ Department of Surgery, Tokushima Breast Care Clinic
長尾, 妙子 Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School
丹黒, 章 Department of Oncological and Regenerative Surgery, Institute of Health Biosciences Department of Surgery, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
breast cancer
capecitabine
dihydropyrimidine dehydrogenase
predictive factor
thymidine phosphorylase
資料タイプ
学術雑誌論文
抄録
Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i.e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
1-2
開始ページ
54
終了ページ
60
並び順
54
発行日
2008-02
EDB ID
192649
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系