ID 110840
Author
Wu, Qishisan Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Harada, Nagakatsu Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Nakamura, Aki Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Yoshida, Masaki Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Mawatari, Kazuaki Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hattori, Atsushi Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Li, Qinkai Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Shimohata, Takaaki Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yinhua Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Lian, Xin Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakano, Masayuki Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Hosaka, Toshio Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Takahashi, Akira Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakaya, Yutaka Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
NO-1886
intestinal contractility
obesity
Content Type
Journal Article
Description
Various intestinal symptoms or diseases are closely associated with intestinal motility, which may be altered by metabolic disturbances associated with diabetes and obesity. It is therefore important that drugs used in the treatment of metabolic disorders should not have any adverse effects on the intestine. In the present study, we examined whether [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (NO-1886), a lipoprotein lipase activator with anti-diabetic and/or anti-obese activity, affects stimulant-induced intestinal contractility. Administration of NO-1886 to intestinal ring preparations of ileum, rectum and colon isolated from Wistar rats attenuated or relaxed contraction induced by a high K+ environment or acetylcholine (ACh). This effect of NO-1886 was dependent on extracellular Ca2+ and intracellular myosin light chain kinase activity. Our results also showed that ACh-induced colonic contraction was significantly higher in the obese Otsuka Long-Evans Tokushima Fatty (OLETF) than in the non-obese Long-Evans Tokushima Otsuka (LETO) rats. The hypercontractility observed in the colons of OLETF rats occurred concomitantly with an elevation in muscarinic M3 ACh receptor protein levels. Administration of NO-1886 attenuated the obesity-induced hypercontractility of the colonic rings of OLETF rats. Thus, intestinal contractile system would be a novel pharmacological target of the lipoprotein lipase activator NO-1886.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
55
Issue
1-2
Start Page
61
End Page
70
Sort Key
61
Published Date
2008-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences