ID 110840
著者
Wu, Qishisan Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
原田, 永勝 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN研究者をさがす
ナカムラ, アキ Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
ヨシダ, マサアキ Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
馬渡, 一諭 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ハットリ, アツシ Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Li, Qinkai Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
下畑, 隆明 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Yinhua Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
Lian, Xin Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
ナカノ, マサユキ Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
保坂, 利男 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School
髙橋, 章 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中屋, 豊 Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
NO-1886
intestinal contractility
obesity
資料タイプ
学術雑誌論文
抄録
Various intestinal symptoms or diseases are closely associated with intestinal motility, which may be altered by metabolic disturbances associated with diabetes and obesity. It is therefore important that drugs used in the treatment of metabolic disorders should not have any adverse effects on the intestine. In the present study, we examined whether [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (NO-1886), a lipoprotein lipase activator with anti-diabetic and/or anti-obese activity, affects stimulant-induced intestinal contractility. Administration of NO-1886 to intestinal ring preparations of ileum, rectum and colon isolated from Wistar rats attenuated or relaxed contraction induced by a high K+ environment or acetylcholine (ACh). This effect of NO-1886 was dependent on extracellular Ca2+ and intracellular myosin light chain kinase activity. Our results also showed that ACh-induced colonic contraction was significantly higher in the obese Otsuka Long-Evans Tokushima Fatty (OLETF) than in the non-obese Long-Evans Tokushima Otsuka (LETO) rats. The hypercontractility observed in the colons of OLETF rats occurred concomitantly with an elevation in muscarinic M3 ACh receptor protein levels. Administration of NO-1886 attenuated the obesity-induced hypercontractility of the colonic rings of OLETF rats. Thus, intestinal contractile system would be a novel pharmacological target of the lipoprotein lipase activator NO-1886.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
1-2
開始ページ
61
終了ページ
70
並び順
61
発行日
2008-02
EDB ID
179205
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系