ID 110856
Author
Sakai, Tohru Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kogiso, Mari Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School
Keywords
soy isoflavone
genistein
immunity
T cell
Content Type
Journal Article
Description
The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17β- estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell -dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
55
Issue
3-4
Start Page
167
End Page
173
Sort Key
167
Published Date
2008-08
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences