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ダウンロード数 : ?
ID 110856
著者
酒井, 徹 Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
小木曽, 真理 Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School
キーワード
soy isoflavone
genistein
immunity
T cell
資料タイプ
学術雑誌論文
抄録
The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17β- estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell -dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
3-4
開始ページ
167
終了ページ
173
並び順
167
発行日
2008-08
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系