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ID 111004
Author
Fukunaga, Eri The University of Tokushima
Ohiwa, Yurie The University of Tokushima
Yamada, Mari The University of Tokushima
Sumi, Ayaka The University of Tokushima
Oyama, Yasuo The University of Tokushima KAKEN Search Researchers
Keywords
N,N-dimethyldodecylamine-N-oxide (DDAO)
cytotoxicity
lymphocyte
Content Type
Departmental Bulletin Paper
Description
N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.
Journal Title
Natural Science Research
ISSN
09146385
NCID
AN10065859
Volume
29
Issue
1
Start Page
1
End Page
4
Sort Key
1
Published Date
2015-01
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry