ID 111004
Author
Fukunaga, Eri The University of Tokushima
Ohiwa, Yurie The University of Tokushima
Yamada, Mari The University of Tokushima
Sumi, Ayaka The University of Tokushima
Keywords
N,N-dimethyldodecylamine-N-oxide (DDAO)
cytotoxicity
lymphocyte
Content Type
Departmental Bulletin Paper
Description
N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.
Journal Title
Natural Science Research
ISSN
09146385
NCID
AN10065859
Volume
29
Issue
1
Start Page
1
End Page
4
Sort Key
1
Published Date
2015-01
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry