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ID 111004
著者
Fukunaga, Eri The University of Tokushima
Ohiwa, Yurie The University of Tokushima
Yamada, Mari The University of Tokushima
Sumi, Ayaka The University of Tokushima
小山, 保夫 The University of Tokushima KAKEN研究者をさがす
キーワード
N,N-dimethyldodecylamine-N-oxide (DDAO)
cytotoxicity
lymphocyte
資料タイプ
紀要論文
抄録
N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.
掲載誌名
自然科学研究
ISSN
09146385
cat書誌ID
AN10065859
29
1
開始ページ
1
終了ページ
4
並び順
1
発行日
2015-01
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系