ID 111008
Author
Oyama, Tomohiro M. Tokushima University
Fukunaga, Eri Tokushima University
Keywords
clioquinol
hydrogen peroxide
cytotoxicity
lymphocyte
Content Type
Departmental Bulletin Paper
Description
We examined the effect of clioquinol on the process of cell death induced by hydrogen peroxide (H2O2) using a flow cytometric technique with propidium iodide and annexin V-FITC in order to see if clioquinol augments the toxicity caused by oxidative stress. Clioquinol (100 nM) alone did not change the process of spontaneous cell death. However, the agent accelerated the process of cell death induced by 300 μM H2O2. Result indicates that clioquinol augments the cytotoxicity induced by H2O2. Therefore, the use of clioquinol may be inadequate for the treatment of some diseases related to oxidative stress.
Journal Title
Natural Science Research
ISSN
09146385
NCID
AN10065859
Volume
29
Issue
3
Start Page
31
End Page
33
Sort Key
31
Published Date
2015-07
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry