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ID 111008
著者
Oyama, Tomohiro M. Tokushima University
Fukunaga, Eri Tokushima University
キーワード
clioquinol
hydrogen peroxide
cytotoxicity
lymphocyte
資料タイプ
紀要論文
抄録
We examined the effect of clioquinol on the process of cell death induced by hydrogen peroxide (H2O2) using a flow cytometric technique with propidium iodide and annexin V-FITC in order to see if clioquinol augments the toxicity caused by oxidative stress. Clioquinol (100 nM) alone did not change the process of spontaneous cell death. However, the agent accelerated the process of cell death induced by 300 μM H2O2. Result indicates that clioquinol augments the cytotoxicity induced by H2O2. Therefore, the use of clioquinol may be inadequate for the treatment of some diseases related to oxidative stress.
掲載誌名
自然科学研究
ISSN
09146385
cat書誌ID
AN10065859
29
3
開始ページ
31
終了ページ
33
並び順
31
発行日
2015-07
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系