ID 111103
Title Alternative
入院慢性腎臓病患者における血清アルブミン濃度に影響を与える因子
Serum albumin, proteinuria in hospitalized CKD patients
Author
Yoshimoto, Sakiya Tokushima University
Shibata, Eriko Tokushima University
Ueda, Sayo Tokushima University
Tamaki, Masanori Tokushima University
Nishimura, Kenji Tokushima University
Obata, Fumiaki Tokushima University
Inagaki, Taizo Tokushima University
Minato, Masanori Tokushima University
Hann, Michael Naval Medical Center San Diego
Keywords
Serum albumin concentration
Proteinuria
Chronic kidney disease
Postural change
Hospitalization
Content Type
Thesis or Dissertation
Description
Background : Serum albumin concentration (SAC) is a prognostic factor that is affected by many factors such as postural change, liver function and food intake. Chronic kidney disease (CKD) patients excrete proteinuria, have low-protein diet, and receive glucocorticoid therapy. No one has evaluated the most influential factors on SAC in CKD patients. Methods : A retrospective study. Hospitalized CKD patients with less than 1 g/ gCreatinine proteinuria receiving glucocorticoid therapy (n=28), with 1 or more g/gCreatinine proteinuria not receiving glucocorticoid therapy (n=36), and with 1 or more g/gCreatinine proteinuria receiving glucocorticoid therapy (n=39) were enrolled. SAC, hemoglobin, proteinuria and blood pressure at the last outpatient check-up before hospitalization, on the second day of hospitalization, at the last laboratory examination before discharge, as well as at the first outpatient follow-up after discharge were analyzed. Results : SAC decreased on the second day of hospitalization and increased at the first outpatient follow-up significantly in all groups. Unexpectedly, the change of SAC was irrelevant to the amount of proteinuria. Conclusions : SAC was affected by not only proteinuria, but also postural change, physical activity, and food in CKD patients. SAC should be analyzed by standardizing a patient’s condition during phlebotomy.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
64
Issue
1-2
Start Page
146
End Page
152
Sort Key
146
Published Date
2017-02
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704171001.pdf
論文本文:LID201704171002.pdf
本論文は,著者Sakiya Yoshimotoの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3029号
Diploma Number
甲医第1333号
Granted Date
2017-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences