ID 111124
Author
Nozoe, Tadahiro Fukuoka Higashi Medical Center
Nozoe, Emiko Saiseikai Fukuoka General Hospital
Kono, Mayuko Fukuoka Higashi Medical Center
Ohga, Takefumi Fukuoka Higashi Medical Center
Ezaki, Takahiro Fukuoka Higashi Medical Center
Keywords
anti-p53 antibody
nuclear grade
triple negative breast cancer
progressive potential
Content Type
Journal Article
Description
Background : Serum appearance of anti-p53 antibody (p53Ab) has been reported as an indicator for progressive potential of human tumor tumors including breast cancer. But its significance in breast cancer has not been discussed fully.Methods : Relationship between serumappearance of p53Abs and representative data accounting for progressive potential in breast cancer, nuclear grade (NG), triple negative cancer, and the cumulative score based on these two data (TGS) was investigated among 129 women with invasive ductal carcinoma (IDC) of the breast, who had been treated with surgical resection. Results : There was a significant correlation between appearance of p53Abs and recurrence of the tumors (P = 0.035). Significant correlation of serum appearance of p53Abs with negative expression of ER (P = 0.011), the proportion of TNBC (P = 0.013), NG (P = 0.017), and TGS (P = 0.0005). Conclusions : Preoperative serum appearance of p53Abs can be correlated with pathological nuclear grade, incidence of triple negative breast cancer, and TGS. These resultsmight demonstrate more powerful significance of serum appearance of p53Abs as an indicator of progressive potential in IDC of the breast.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
64
Issue
3-4
Start Page
241
End Page
244
Sort Key
241
Published Date
2017-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher