ID 111124
著者
Nozoe, Tadahiro Fukuoka Higashi Medical Center
Nozoe, Emiko Saiseikai Fukuoka General Hospital
Kono, Mayuko Fukuoka Higashi Medical Center
Ohga, Takefumi Fukuoka Higashi Medical Center
Ezaki, Takahiro Fukuoka Higashi Medical Center
キーワード
anti-p53 antibody
nuclear grade
triple negative breast cancer
progressive potential
資料タイプ
学術雑誌論文
抄録
Background : Serum appearance of anti-p53 antibody (p53Ab) has been reported as an indicator for progressive potential of human tumor tumors including breast cancer. But its significance in breast cancer has not been discussed fully.Methods : Relationship between serumappearance of p53Abs and representative data accounting for progressive potential in breast cancer, nuclear grade (NG), triple negative cancer, and the cumulative score based on these two data (TGS) was investigated among 129 women with invasive ductal carcinoma (IDC) of the breast, who had been treated with surgical resection. Results : There was a significant correlation between appearance of p53Abs and recurrence of the tumors (P = 0.035). Significant correlation of serum appearance of p53Abs with negative expression of ER (P = 0.011), the proportion of TNBC (P = 0.013), NG (P = 0.017), and TGS (P = 0.0005). Conclusions : Preoperative serum appearance of p53Abs can be correlated with pathological nuclear grade, incidence of triple negative breast cancer, and TGS. These resultsmight demonstrate more powerful significance of serum appearance of p53Abs as an indicator of progressive potential in IDC of the breast.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
64
3-4
開始ページ
241
終了ページ
244
並び順
241
発行日
2017-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版