ID 111269
Author
Watanabe, Masanari Tottori University
Kurai, Jun Tottori University
Minato, Sayaka Tottori Prefectural Institute of Health and Environment
Noma, Hisashi Institute of Statistical Mathematics
Sano, Hiroyuki Kindai University
Saito, Rumiko Tohoku University
Aiba, Setsuya Tohoku University
Oshimura, Mitsuo Tottori University
Hatakeyama, Keisuke Tottori Prefectural Institute of Health and Environment
Yamasaki, Akira Tottori University
Shimizu, Eiji Tottori University
Keywords
particulate matter
pro-inflammatory cytokine
interleukin-8
Content Type
Journal Article
Description
Background : Airborne particulate matter (PM) may stimulate production of pro-inflammatory cytokines, and thus exposure to PM affects pulmonary diseases. However, the effects of PM on pulmonary diseases have differed among studies. Methods : PM was collected from February 2 to 28 (winter) and June 1 to 17 (summer) in 2013 in Yurihama, Japan, using filters to separate particles with different aerodynamic diameters (1.1 to< 2.2 μm, 2.2 to< 3.3 μm, 3.3 to< 7.0 μm, and 7.0 to< 10 μm). Interleukin (IL)-8 transcriptional activity in THP-G8 cells was examined in response to winter and summer PM with different diameters. Results : IL-8 transcriptional activity induced by winter PM was significantly higher than that with summer PM for each diameter. For winter PM, IL-8 activity increased with an increased diameter, whereas this activity did not differ between a solvent control and each summer PM diameter. This indicates that summer PM does not stimulate production of IL-8 in THP-G8 cells. Conclusion : The effects of PM on production of pro-inflammatory cytokines differ with the season and PM diameter. This suggests that the compositions of PM differ on season, and the evaluation of compositions of PM is important in understanding the association of health with short-term exposure to PM.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
145
End Page
148
Sort Key
145
Published Date
2015-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher