ID 111338
Author
Koyama, Noriko Asahi University
Hayashi, Toru Asahi University
Gresik, Edward W The City University of New York Medical School
Kashimata, Masanori Asahi University
Keywords
α6 integrin
Branching morphogenesis
Cleft formation
Stalk elongation
Submandibular gland
Content Type
Journal Article
Description
The submandibular gland (SMG) of the fetal mouse is a well-studied model for the epithelial-mesenchymal interactions required for branching morphogenesis (BrM), which involves cleft formation and stalk elongation. In a previous report, we showed that α6 integrin subunit is involved in BrM of this gland rudiment, since the neutralizing antibody against α6 integrin subunit, GoH3, strongly inhibited branching of cultured intact E13 SMG. In this study, we investigated whether GoH3 inhibits cleft formation and/ or stalk elongation during BrM of cultured mesenchyme-free epithelial rudiments of fetal SMG and also analyzed by Western blotting the levels of phosphorylation of ERK1/2, which is a signaling molecule known to regulate BrM of the fetal mouse SMG.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
247
End Page
249
Sort Key
247
Published Date
2009-12
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher