ID 111359
Author
Gee, Heon Yung Yonsei University College of Medicine
Park, Hyun Woo Yonsei University College of Medicine
Kim, Kyung Hwan Yonsei University College of Medicine
Lee, Min Goo Yonsei University College of Medicine
Keywords
PDZ domain
CFTR
NHE3
VPAC
S-SCAM/MAGI-2
Content Type
Journal Article
Description
Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
302
End Page
305
Sort Key
302
Published Date
2009-12
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher