ID 111359
著者
Gee, Heon Yung Yonsei University College of Medicine
Park, Hyun Woo Yonsei University College of Medicine
Kim, Kyung Hwan Yonsei University College of Medicine
Lee, Min Goo Yonsei University College of Medicine
キーワード
PDZ domain
CFTR
NHE3
VPAC
S-SCAM/MAGI-2
資料タイプ
学術雑誌論文
抄録
Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
56
Supplement
開始ページ
302
終了ページ
305
並び順
302
発行日
2009-12
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版