ID 111364
Author
Kannuki, Seiji the University of Tokushima
Matsumoto, Keizo the University of Tokushima
Shintani, Yasumi the University of Tokushima
Bando, Hiroshi the University of Tokushima KAKEN Search Researchers
Saito, Shiro the University of Tokushima
Keywords
pituitary adenoma
double pituitary adenoma
multiple endocrine neoplasia type 1
Content Type
Journal Article
Description
A 43-year-old male and a 39-year-old male presented with multiple pituitary adenomas with two distinct histological types. The first patient who had multiple endocrine neoplasia type 1 had developed acromegaly due to a growth hormone-releasing hormone (GHRH)-producing pancreatic tumor. Both plasma GHRH and growth hormone (GH) levels decreased to normal after resection of the pancreatic tumor. However, the plasma GH level gradually increased again and magnetic resonance imaging revealed pituitary adenoma formation. Histological examination revealed two different histological types of pituitary adenoma: GH cell adenoma and null cell adenoma. The second patient, with no such genetic condition, had a non-functioning pituitary adenoma. Histological examination revealed two different histological types of silent GH cell adenoma and silent gonadotroph adenoma. Careful histological examination is required to exclude the possibility of multiple pituitary adenomas.
Journal Title
Neurologia medico-chirurgica
ISSN
04708105
13498029
NCID
AN00358613
Publisher
The Japan Neurosurgical Society
Volume
36
Issue
11
Start Page
818
End Page
821
Published Date
1996
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences