ID 111462
Title Alternative
TWO PITUITARY ADENOMAS IN MEN 1
Author
Shintani, Yasumi The University of Tokushima
Horie, Hideaki The University of Tokushima
Kanesaki, Yoshiko The University of Tokushima
Hosoi, Emiko The University of Tokushima
Yokogoshi, Yutaka The University of Tokushima
Bando, Hiroshi The University of Tokushima KAKEN Search Researchers
Iwahana, Hiroyuki The University of Tokushima
Kannuki, Seiji The University of Tokushima
Matsumoto, Keizo The University of Tokushima
Saito, Shiro The University of Tokushima
Keywords
MEN 1
Pituitary adenoma
Ectopic GHRH-producing tumor
Loss of heterozygosity
Chromosome 11
Content Type
Journal Article
Description
The clinical and genetic features of a 43-year-old male patient with multiple endocrine neoplasia type 1 were reported. He developed hyperparathyroidism, a GHRH-producing pancreatic tumor, and acromegaly between 1980 and 1983. Because his pituitary gland increased in size even after resecting the GHRH-producing pancreatic tumor, transsphenoidal hypophysectomy was performed six years later. The pituitary contained two histologically-different adenomas composed of somatotroph cells and null cells. Genetic analyses revealed loss of heterozygosity on chromosome 11 in common in the pituitary adenomas, the pancreatic endocrine tumors, and a parathyroid hyperplasia. On the other hand, mutations of ras, p53, Gsα, and Gi2α genes were not found in these tumors. The loss of the tumor suppressor gene on chromosome 11q12-13 was involved in the formation of two pituitary adenomas, two pancreatic endocrine functioning tumors, and a parathyroid hyperplasia in this patient, but the tumorigenic factors in the specific endocrine organs remain to be studied.
Journal Title
Endocrine Journal
ISSN
13484540
09188959
NCID
AA10901436
Publisher
The Japan Endocrine Society
Volume
42
Issue
3
Start Page
331
End Page
340
Published Date
1995
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Medical Sciences
Institute of Advanced Medical Sciences