ID 111488
Author
Karabasil, Mileva R The University of Tokushima|Belgrade University
Murdiastuti, Kwartarini Gadjah Mada University
Purwanti, Nunuk The University of Tokushima|Gadjah Mada University
Azlina, Ahmad The University of Tokushima
Purevjav, Javkhlan The University of Tokushima
Keywords
AQP5 mutant
trafficking
salivary gland
Content Type
Journal Article
Description
In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of 103Gly with 103Asp in the 3rd transmembrane domain. The mutant molecule scarcely expressed in the acinar cells, probably because of ineffective trafficking. The mutant molecule, however, showed normal water permeability when assessed by the oocyte system.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
56
Issue
Supplement
Start Page
398
End Page
400
Sort Key
398
Published Date
2009-12
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences
Bioscience and Bioindustry