ID 111553
Author
Turck, Christoph W Max Planck Institute of Psychiatry
Maccarrone, Giuseppina Max Planck Institute of Psychiatry
Sayan-Ayata, Eser Max Planck Institute of Psychiatry
Jacob, Archana M Max Planck Institute of Psychiatry
Ditzen, Claudia Max Planck Institute of Psychiatry
Kronsbein, Helena Max Planck Institute of Psychiatry
Birg, Isabel Max Planck Institute of Psychiatry
Doertbudak, Can-Carlo Max Planck Institute of Psychiatry
Haegler, Katrin Max Planck Institute of Psychiatry
Lebar, Maria Max Planck Institute of Psychiatry
Teplytska, Larysa Max Planck Institute of Psychiatry
Kolb, Nik Max Planck Institute of Psychiatry
Uwaje, Nkemdilim Max Planck Institute of Psychiatry
Zollinger, Richard Max Planck Institute of Psychiatry
Keywords
brain disease
biomarkers
proteomics
Content Type
Journal Article
Description
The identification of disease markers in tissues and body fluids requires an extensive and thorough analysis of its protein constituents. In our efforts to identify biomarkers for affective and neurological disorders we are pursuing several different strategies. On one hand we are using animal models that represent defined phenotypes charactersistic for the respective disorder in humans. In addition, we are analyzing human specimens from carefully phenotyped patient groups. Several fractions representing different protein classes from human cerebrospinal fluid obtained by lumbar puncture are used for this purpose. Our biomarker identification efforts range from classical proteomics approaches such as two dimensional gel electrophoresis and mass spectrometry to phage display screens with cerebrospinal fluid antibodies.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
52
Issue
Supplement
Start Page
231
End Page
235
Sort Key
231
Published Date
2005-11
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng