ID 111553
著者
Turck, Christoph W Max Planck Institute of Psychiatry
Maccarrone, Giuseppina Max Planck Institute of Psychiatry
Sayan-Ayata, Eser Max Planck Institute of Psychiatry
Jacob, Archana M Max Planck Institute of Psychiatry
Ditzen, Claudia Max Planck Institute of Psychiatry
Kronsbein, Helena Max Planck Institute of Psychiatry
Birg, Isabel Max Planck Institute of Psychiatry
Doertbudak, Can-Carlo Max Planck Institute of Psychiatry
Haegler, Katrin Max Planck Institute of Psychiatry
Lebar, Maria Max Planck Institute of Psychiatry
Teplytska, Larysa Max Planck Institute of Psychiatry
Kolb, Nik Max Planck Institute of Psychiatry
Uwaje, Nkemdilim Max Planck Institute of Psychiatry
Zollinger, Richard Max Planck Institute of Psychiatry
キーワード
brain disease
biomarkers
proteomics
資料タイプ
学術雑誌論文
抄録
The identification of disease markers in tissues and body fluids requires an extensive and thorough analysis of its protein constituents. In our efforts to identify biomarkers for affective and neurological disorders we are pursuing several different strategies. On one hand we are using animal models that represent defined phenotypes charactersistic for the respective disorder in humans. In addition, we are analyzing human specimens from carefully phenotyped patient groups. Several fractions representing different protein classes from human cerebrospinal fluid obtained by lumbar puncture are used for this purpose. Our biomarker identification efforts range from classical proteomics approaches such as two dimensional gel electrophoresis and mass spectrometry to phage display screens with cerebrospinal fluid antibodies.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
52
Supplement
開始ページ
231
終了ページ
235
並び順
231
発行日
2005-11
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng