number of access : ?
number of downloads : ?
ID 111810
Title Alternative
MRマイクロイメージングとガドリニウム-デンドロン修飾ナノリポソーム造影剤を用いた3D微小血管およびナノ粒子分布の腫瘍内評価
Author
Nitta, Nobuhiro Tokushima University|National Institutes for Quantum and Radiological Science and Technology (QST)
Takakusagi, Yoichi National Institutes for Quantum and Radiological Science and Technology (QST)
Kokuryo, Daisuke Fujita Health University School of Medicine
Shibata, Sayaka National Institutes for Quantum and Radiological Science and Technology (QST)
Tomita, Akihiro Tokushima University
Higashi, Tatsuya National Institutes for Quantum and Radiological Science and Technology (QST)
Aoki, Ichio National Institutes for Quantum and Radiological Science and Technology (QST)
Keywords
liposomal contrast agent
tumor heterogeneity
angiography
MRI
EPR
Content Type
Thesis or Dissertation
Description
The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent. Using the Gd-liposome and a cryogenic receiving coil, we achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between Colon26- and SU-DHL6-grafted mice models. The vessel volumes and diameters measured for both tumors were significantly correlated with histological observations. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.
Journal Title
Nanomedicine : Nanotechnology, Biology and Medicine
ISSN
15499634
NCID
AA11976408
AA12726723
Publisher
Elsevier
Volume
14
Issue
4
Start Page
1315
End Page
1324
Published Date
2018-04-04
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Nobuhiro Nittaの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© 2018 . Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3200号
Diploma Number
甲医第1375号
Granted Date
2018-05-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences