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ID 111810
タイトル別表記
MRマイクロイメージングとガドリニウム-デンドロン修飾ナノリポソーム造影剤を用いた3D微小血管およびナノ粒子分布の腫瘍内評価
著者
新田, 展大 徳島大学大学院医科学教育部(医学専攻)
Takakusagi, Yoichi National Institutes for Quantum and Radiological Science and Technology (QST)
Kokuryo, Daisuke Fujita Health University School of Medicine
Shibata, Sayaka National Institutes for Quantum and Radiological Science and Technology (QST)
Tomita, Akihiro Tokushima University
Higashi, Tatsuya National Institutes for Quantum and Radiological Science and Technology (QST)
Aoki, Ichio National Institutes for Quantum and Radiological Science and Technology (QST)
キーワード
liposomal contrast agent
tumor heterogeneity
angiography
MRI
EPR
資料タイプ
学位論文
抄録
The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent. Using the Gd-liposome and a cryogenic receiving coil, we achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between Colon26- and SU-DHL6-grafted mice models. The vessel volumes and diameters measured for both tumors were significantly correlated with histological observations. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.
掲載誌名
Nanomedicine : Nanotechnology, Biology and Medicine
ISSN
15499634
cat書誌ID
AA11976408
AA12726723
出版者
Elsevier
14
4
開始ページ
1315
終了ページ
1324
発行日
2018-04-04
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Nobuhiro Nittaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2018 . Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3200号
学位記番号
甲医第1375号
学位授与年月日
2018-05-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系