| ID | 111876 |
| Title Alternative | Facile Guanidine Formation under Mild Acidic Condition
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| Author |
Takeuchi, Kohei
Hokkaido University
Nakayama, Atsushi
Tokushima University
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Tanino, Keiji
Hokkaido University
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| Keywords | guanidinylation
cyclic guanidine
isothiourea
bis(trifluoromethansulfonyl)imide
ammonium bis(trifluoromethansulfonyl)imidate
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| Content Type |
Journal Article
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| Description | An efficient method for converting isothioureas into guanidines was developed. The use of amine salts of bis(trifluoromethanesulfonyl)imide as a nitrogen source was found to induce an efficient conversion under weak acidic condition at 50 °C. The conversion was applicable to the various amines and carbamate-protected thioureas, and various carbamate-protected cyclic guanidines were obtained in high yields. In particular, ammonium bis(trifluoromethanesulfonyl)imide salt is a useful N1 source with which to construct mono-protected cyclic guanidines.
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| Journal Title |
Synlett
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| ISSN | 09365214
14372096
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| NCID | AA10731110
AA12357740
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| Publisher | Thieme
|
| Volume | 27
|
| Issue | 18
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| Start Page | 2591
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| End Page | 2596
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| Published Date | 2016-08-01
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| Rights | © 2016 Georg Thieme Verlag Stuttgart · New York
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Author
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| departments |
Pharmaceutical Sciences
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