ID 111879
Title Alternative
Development of an anilide-type scaffold for the thioester precursor, N-Sulfanylethylcoumarinyl amide (SECmide)
Author
Eto, Mitsuhiro Tokushima University
Naruse, Naoto Tokushima University
Morimoto, Kyohei Tokushima University
Yamaoka, Kosuke Tokushima University
Sato, Kohei Tokushima University|Shizuoka University
Tsuji, Kohei Tokushima University|National Institutes of Health
Shigenaga, Akira Tokushima University|Japan Science and Technology Agency (JST) Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Content Type
Journal Article
Description
N-Sulfanylethylcoumarinyl amide (SECmide) peptide, which was initially developed for the use in the fluorescence-guided detection of promoters of N–S acyl transfer, was successfully applied to a facile and side reaction-free protocol for N–S acyl-transfer-mediated synthesis of peptide thioesters. Additionally, 4-mercapto benzyl phosphonic acid (MBPA) was proved to be a useful catalyst for the SECmide or N-sulfanylethylanilide (SEAlide)-mediated NCL reaction.
Journal Title
Organic Letters
ISSN
15237060
15237052
NCID
AA11347843
AA1218968X
Publisher
ACS publications
Volume
18
Issue
17
Start Page
4416
End Page
4419
Published Date
2016-08-16
Rights
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.6b02207.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences