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  2. Otaka, Akira

Otaka, Akira

Published Date (desc)
Cysteinylprolyl ester-mediated drug release from a lipid–drug conjugate
Author Tsuji, Takashi/ Inazuki, Hayato/ Kobayashi, Daishiro/ Hayashi, Junya/ Denda, Masaya/ Otaka, Akira/
Content Type Journal Article
Journal Title Bioorganic & Medicinal Chemistry Letters
Volume 109
Published Date 2024-06-13
departments Pharmaceutical Sciences
Late-Stage Formation of a Sactionine Linkage Enabled by Lossen Rearrangement of Glycyl Hydroxamic Acid
Author Hayashi, Junya/ Kobayashi, Daishiro/ Denda, Masaya/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 26
Issue 24
Published Date 2024-06-07
departments Pharmaceutical Sciences
Synthesis of N-Glyoxylyl Peptides Enabled by a Lossen Rearrangement-Induced Intramolecular Redox Reaction of N-Terminal Glycyl Hydroxamic Acid
Author Hayashi, Junya/ Kobayashi, Daishiro/ Namikawa, Chizuru/ Denda, Masaya/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 26
Issue 20
Published Date 2024-05-13
departments Pharmaceutical Sciences
Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide
Author Hidaka, Kota/ Kobayashi, Daishiro/ Hayashi, Junya/ Denda, Masaya/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 30
Issue 39
Published Date 2024-04-29
departments Pharmaceutical Sciences
Identification of Low-Density Lipoprotein Receptor-Related Protein 1 as a CXCL14 Receptor Using Chemically Synthesized Tetrafunctional Probes
Author Miyajima, Rin/ Tanegashima, Kosuke/ Naruse, Naoto/ Denda, Masaya/ Hara, Takahiko/ Otaka, Akira/
Content Type Journal Article
Journal Title ACS Chemical Biology
Volume 19
Issue 2
Published Date 2024-01-30
departments Pharmaceutical Sciences
CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses
Author Imanishi, Masaki/ Inoue, Takahisa/ Fukushima, Keijo/ Yamashita, Ryosuke/ Nakayama, Ryo/ Nojima, Masataka/ Kondo, Kosuke/ Gomi, Yoshiki/ Tsunematsu, Honoka/ Goto, Kohei/ Miyamoto, Licht/ Funamoto, Masafumi/ Denda, Masaya/ Ishizawa, Keisuke/ Otaka, Akira/ Fujino, Hiromichi/ Ikeda, Yasumasa/ Tsuchiya, Koichiro/
Content Type Journal Article
Journal Title Journal of Pharmacological Sciences
Volume 153
Issue 4
Published Date 2023-10-17
departments University Hospital Pharmaceutical Sciences Medical Sciences
Residue-selective C−H sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence
Author Ohkawachi, Kento/ Anzaki, Kaito/ Kobayashi, Daishiro/ Kyan, Ryuji/ Yasuda, Takuma/ Denda, Masaya/ Harada, Norio/ Shigenaga, Akira/ Inagaki, Nobuya/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 29
Issue 26
Published Date 2023-03-15
departments Pharmaceutical Sciences
Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety
Author Yamasaki, Misaki/ Seto, Yuika/ Ozono, Mizune/ Nakao, Michiyasu/ Shigenaga, Akira/ Otaka, Akira/ Sano, Shigeki/ Kogure, Kentaro/
Content Type Journal Article
Journal Title Biochemistry and Biophysics Reports
Volume 31
Published Date 2022-08-16
departments Pharmaceutical Sciences
S-Protected Cysteine Sulfoxide-Enabled Tryptophan-Selective Modification with Application to Peptide Lipidation
Author Kobayashi, Daishiro/ Kuraoka, Eisuke/ Hayashi, Junya/ Yasuda, Takuma/ Kohmura, Yutaka/ Denda, Masaya/ Harada, Norio/ Inagaki, Nobuya/ Otaka, Akira/
Content Type Journal Article
Journal Title ACS Medicinal Chemistry Letters
Volume 13
Issue 7
Published Date 2022-06-14
departments Pharmaceutical Sciences
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
Author Miyake, Masato/ Sobajima, Mitsuaki/ Kurahashi, Kiyoe/ Shigenaga, Akira/ Denda, Masaya/ Otaka, Akira/ Saio, Tomohide/ Sakane, Naoki/ Kosako, Hidetaka/ Oyadomari, Seiichi/
Content Type Journal Article
Journal Title Cell Chemical Biology
Volume 29
Issue 6
Published Date 2022-02-09
departments Institute of Advanced Medical Sciences University Hospital Pharmaceutical Sciences
Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation
Author Sato, Daiki/ Denda, Masaya/ Tsunematsu, Honoka/ Tanaka, Naonobu/ Konishi, Isamu/ Komiya, Chiaki/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 58
Issue 17
Published Date 2022-02-01
departments Pharmaceutical Sciences Bioscience and Bioindustry
Copper (II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides
Author Kobayashi, Daishiro/ Kohmura, Yutaka/ Hayashi, Junya/ Denda, Masaya/ Tsuchiya, Koichiro/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 57
Issue 82
Published Date 2021-09-17
departments Pharmaceutical Sciences
Peptide Cyclization Mediated by Metal-Free S-Arylation : S-Protected Cysteine Sulfoxide as an Umpolung of the Cysteine Nucleophile
Author Kobayashi, Daishiro/ Kohmura, Yutaka/ Sugiki, Toshihiko/ Kuraoka, Eisuke/ Denda, Masaya/ Fujiwara, Toshimichi/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 27
Issue 56
Published Date 2021-07-23
departments Pharmaceutical Sciences
Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions
Author Kobayashi, Daishiro/ Naruse, Naoto/ Denda, Masaya/ Shigenaga, Akira/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic & Biomolecular Chemistry
Volume 18
Issue 42
Published Date 2020-08-20
departments Pharmaceutical Sciences
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis
Author Ohkawachi, Kento/ Kobayashi, Daishiro/ Morimoto, Kyohei/ Shigenaga, Akira/ Denda, Masaya/ Yamatsugu, Kenzo/ Kanai, Motomu/ Otaka, Akira/
Content Type Journal Article
Journal Title Organic Letters
Volume 22
Issue 14
Published Date 2020-05-12
departments Pharmaceutical Sciences
Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent
Author Nakayama, Atsushi/ Otani, Akira/ Inokuma, Tsubasa/ Tsuji, Daisuke/ Mukaiyama, Haruka/ Nakayama, Akira/ Itoh, Kohji/ Otaka, Akira/ Tanino, Keiji/ Namba, Kosuke/
Content Type Journal Article
Journal Title Communications Chemistry
Volume 3
Published Date 2020-01-09
departments Pharmaceutical Sciences
Asymmetric Synthesis of α‐Amino Phosphonic Acids using Stable Imino Phosphonate as a Universal Precursor
Author Inokuma, Tsubasa/ Sakakibara, Takuya/ Someno, Takatoshi/ Masui, Kana/ Shigenaga, Akira/ Otaka, Akira/ Yamada, Ken-ichi/
Content Type Journal Article
Journal Title Chemistry- A European Journal
Volume 25
Issue 60
Published Date 2019-08-26
departments Pharmaceutical Sciences
Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence
Author Komiya, Chiaki/ Shigenaga, Akira/ Tsukimoto, Jun/ Ueda, Masahiro/ Morisaki, Takuya/ Inokuma, Tsubasa/ Itoh, Kohji/ Otaka, Akira/
Content Type Journal Article
Journal Title Chemical Communications
Volume 55
Issue 49
Published Date 2019-05-23
departments Pharmaceutical Sciences
A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst
Author Jichu, Takahisa/ Inokuma, Tsubasa/ Aihara, Keisuke/ Kohiki, Taiki/ Nishida, Kodai/ Shigenaga, Akira/ Yamada, Ken-ichi/ Otaka, Akira/
Content Type Journal Article
Journal Title ChemCatChem
Volume 10
Issue 16
Published Date 2018-07-11
departments Pharmaceutical Sciences
Light-induced propulsion of a giant liposome driven by peptide nanofibre growth
Author Inaba, Hiroshi/ Uemura, Akihito/ Morishita, Kazushi/ Kohiki, Taiki/ Shigenaga, Akira/ Otaka, Akira/ Matsuura, Kazunori/
Content Type Journal Article
Journal Title Scientific Reports
Volume 8
Published Date 2018-04-19
departments Pharmaceutical Sciences
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