ID 111937
Author
Keywords
Xerostomia
Aquaporin-5
Functional foods
Secretagogues
Content Type
Journal Article
Description
Xerostomia, or dry mouth, is mainly caused by systemic disease, biological aging, and drug-induced side effect. The innervations underlying the three major salivary glands and numerous minor salivary glands differ substantially. The trafficking of aquaporin-5 (AQP5), which is specifically expressed in salivary glands, is regulated by the autonomic nerves. Upon the stimulation of the cholinergic nerve, AQP5 travels to apical and lateral plasma membranes, nuclei, and saliva. In this review article, I will describe the subcellular localization of AQP5 in relation to the causes of xerostomia. Ways of managing xerostomia, in particular the use of functional foods and salivary secretagogues, are also discussed.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
四国歯学会
Volume
31
Issue
1
Start Page
49
End Page
56
Sort Key
49
Published Date
2018-07-05
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences