ID 112014
Title Alternative
Endogenous regulator for nitric oxide synthesis, methylated arginines and its metabolism : physiological function of unusual amino acids derived from proteins methylated posttranslationally
内因性一酸化窒素産性制御因子
Author
Ogawa, Tadashi The University of Tokushima
Keywords
nitric oxide
nitric oxide synthase
methylated arginines
post-translational modification
endogenous inhibitors
Content Type
Journal Article
Description
Nitric oxide is synthesized in various tissues and plays a role in wide and diverse range of physiological process such as vasodilation at cardiovascular system, inhibition of platelet aggregation, cytotoxic effect of phagocytic cells,and so on. Remarkable progress in the studies on a biological function of nitric oxide have been made by the technical use of various inhibitor of nitric oxide synthase. Now the interest in the possibility, that the inhibitors of nitric oxide synthase may be the important drugs for the various diseases, is growing in the field of clinical invesigation of nitric oxide. In this review, the properties of the endogenous inhibitors, NG-monomethyl-L-arginine and NG, NG-dimethyl-L-arginine which are derived from the proteins methylated post-translationally, and their metabolic significance including the enzyme, dimethylarginine dimethylaminohydrolase as a possible regulatory system of nitric oxide function in tissues.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
53
Issue
6
Start Page
277
End Page
284
Sort Key
277
Published Date
1997-12-25
FullText File
language
jpn
TextVersion
Publisher