ID 112029
Title Alternative
Auditory Evoked Potential (AEP) in Manic Depressive Illness (MDI)
躁うつ病患者の聴覚性誘発電位
Author
Okada, Ken The University of Tokushima
Yoshimatsu, Makoto The University of Tokushima
Okura, Masao The University of Tokushima
Ikuta, Takumi The University of Tokushima
Kawabata, Shigeo The University of Tokushima
Keywords
auditory evoked potentials
MDI
sexes
lithium
carbamazepine
Content Type
Journal Article
Description
The differences between MDI patients and healthy subjects in Auditory Evoked Potential (AEP) were studied with 45 MDI subjects (22 males and 23 females) and 60 healthy subjects (30 males and 30 females). AEPs were recorded through the two deviations (3 rd CH : Cz→A1+2 and 6 th CH : Cz→T5), together with EEG. The following results were obtained.
1. Almost of the peak latencies of AEP components were longer in MDI subjects than those in healthy ones, both in males and females. The interpeak amplitude N2-P3 and P4-N4 in both derivations were significantly larger in male patients. The predominant amplitude N4-P5 and P5-N5 in both derivations significantly small in females.
2. Furthermore, there were little significant differences between AEP recorded in manic and depressive condition of the patients.
3. There were little significant differences in AEP between the patients treated regularly with lithium or carbamazepine and not, and between who had the clinical history more than 2 years and not.
These results indicate some dysfunctions in reticular formation, thalamus, up to the primary and secondary auditory cortex in MDI. suggesting the single pathophysiological basis under laying manic-depressive illness.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
54
Issue
1
Start Page
63
End Page
74
Sort Key
63
Published Date
1998-02-25
FullText File
language
jpn
TextVersion
Publisher