躁うつ病患者(MDI)の聴覚性誘発電位(AEP)

The differences between MDI patients and healthy subjects in Auditory Evoked Potential (AEP) were studied with 45 MDI subjects (22 males and 23 females) and 60 healthy subjects (30 males and 30 females). AEPs were recorded through the two deviations (3 rd CH : Cz→A1+2 and 6 th CH : Cz→T5), together with EEG. The following results were obtained.
1. Almost of the peak latencies of AEP components were longer in MDI subjects than those in healthy ones, both in males and females. The interpeak amplitude N2-P3 and P4-N4 in both derivations were significantly larger in male patients. The predominant amplitude N4-P5 and P5-N5 in both derivations significantly small in females.
2. Furthermore, there were little significant differences between AEP recorded in manic and depressive condition of the patients.
3. There were little significant differences in AEP between the patients treated regularly with lithium or carbamazepine and not, and between who had the clinical history more than 2 years and not.
These results indicate some dysfunctions in reticular formation, thalamus, up to the primary and secondary auditory cortex in MDI. suggesting the single pathophysiological basis under laying manic-depressive illness.