Suppression of human immunodeficiency virus type 1 replication by its mutants
Adachi, Akio The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Inubushi, Ritsuko The University of Tokushima
Shimano, Reika The University of Tokushima
Various mutants of human immunodeficiency type 1 (HIV-1) were systematically analyzed with respect to their ability to suppress the replication of wild-type (wt) HIV-1. A total of thirty-six mutants of all nine HIV-1 genes were evaluated for their inhibitory effects in a single-round of viral replication cycle. Some of the gag and env mutants were found to be efficiently interfere with the replication of wt HIV-1. The effective sites were mapped to early and/or late viral replication phase. These mutants are useful for future gene therapy against HIV-1 disease AIDS.
Shikoku Acta Medica
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