ID 112090
タイトル別表記
Suppression of human immunodeficiency virus type 1 replication by its mutants
変異体によるHIV-1の複製抑制
著者
犬伏, 理津子 徳島大学
島野, 玲香 徳島大学
キーワード
HIV-1
Gag
Env
gene therapy
資料タイプ
学術雑誌論文
抄録
Various mutants of human immunodeficiency type 1 (HIV-1) were systematically analyzed with respect to their ability to suppress the replication of wild-type (wt) HIV-1. A total of thirty-six mutants of all nine HIV-1 genes were evaluated for their inhibitory effects in a single-round of viral replication cycle. Some of the gag and env mutants were found to be efficiently interfere with the replication of wt HIV-1. The effective sites were mapped to early and/or late viral replication phase. These mutants are useful for future gene therapy against HIV-1 disease AIDS.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
54
4
開始ページ
282
終了ページ
287
並び順
282
発行日
1998-08-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系