ID 112145
Title Alternative
腎細動脈レベルでのアデノシン受容体
Adenosine receptors in the isolated rabbit afferent and efferent arterioles
Author
Inui, Daisuke The University of Tokushima KAKEN Search Researchers
Kirima, Kazuyoshi The University of Tokushima
Ozawa, Yuichi The University of Tokushima
Suzaki, Yuki The University of Tokushima
Hasegawa, Toyoshi The University of Tokushima
Yoshizumi, Masanori The University of Tokushima
Keywords
adenosine receptor
afferent arteriole
efferent arteriole
KW-3902
KF 17837
Content Type
Journal Article
Description
Adenosine has been noted as one of the endogenous modulators of renal hemodynamics. Renal hemodynamic was mainly regulated by two resistance vessels, the afferent arteriole and efferent arteriole. However, there is still no consensus as to the intrarenal vascular action site of adenosine. In this study, we examined the direct effect of adenosine on the isolated microperfused rabbit afferent and efferent arterioles. Adenosine decreased the lumen diameter of microperfused afferent arterioles dose-dependently (Control : 14.35±0.97μm, adenosine 10-7M : 12.73±1.40μm, 10-6M : 8.18±1.21μm, 10-5M : 4.33±1.16μm, n=6). Adenosine increased the lumen diameter of adenosine A1 antagonist, 8-(normantan-3-yl)-1,3-dipropylxanthin (KW-3902), pretreated-microperfused afferent arterioles preconstricted by norepinephrine. Pretreatment with adenosine A2 antagonist, (E)-1,3,-dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthin (KF-7837), enhanced adenosine induced-afferent arteriolar vasoconstrictor effect. Adenosine did not change the lumen diameter of microperfused efferent arterioles, but adenosine increased the lumen diameter of norepinephrine preconstricted-microperfused efferent arterioles. The present data suggest that the afferent arterioles possesses both adenosine A1 and A2 receptors and the efferent arterioles possesses predominantly adenosine A2 receptors at least in the rabbit kidney.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
55
Issue
3
Start Page
124
End Page
130
Sort Key
124
Published Date
1999-06-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Pharmaceutical Sciences
Medical Sciences