ID 112145
タイトル別表記
腎細動脈レベルでのアデノシン受容体
Adenosine receptors in the isolated rabbit afferent and efferent arterioles
著者
桐間, 一嘉 徳島大学
小澤, 祐一 徳島大学
須崎, 友紀 徳島大学
長谷川, 豊司 徳島大学
吉栖, 正典 徳島大学
キーワード
adenosine receptor
afferent arteriole
efferent arteriole
KW-3902
KF 17837
資料タイプ
学術雑誌論文
抄録
Adenosine has been noted as one of the endogenous modulators of renal hemodynamics. Renal hemodynamic was mainly regulated by two resistance vessels, the afferent arteriole and efferent arteriole. However, there is still no consensus as to the intrarenal vascular action site of adenosine. In this study, we examined the direct effect of adenosine on the isolated microperfused rabbit afferent and efferent arterioles. Adenosine decreased the lumen diameter of microperfused afferent arterioles dose-dependently (Control : 14.35±0.97μm, adenosine 10-7M : 12.73±1.40μm, 10-6M : 8.18±1.21μm, 10-5M : 4.33±1.16μm, n=6). Adenosine increased the lumen diameter of adenosine A1 antagonist, 8-(normantan-3-yl)-1,3-dipropylxanthin (KW-3902), pretreated-microperfused afferent arterioles preconstricted by norepinephrine. Pretreatment with adenosine A2 antagonist, (E)-1,3,-dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthin (KF-7837), enhanced adenosine induced-afferent arteriolar vasoconstrictor effect. Adenosine did not change the lumen diameter of microperfused efferent arterioles, but adenosine increased the lumen diameter of norepinephrine preconstricted-microperfused efferent arterioles. The present data suggest that the afferent arterioles possesses both adenosine A1 and A2 receptors and the efferent arterioles possesses predominantly adenosine A2 receptors at least in the rabbit kidney.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
55
3
開始ページ
124
終了ページ
130
並び順
124
発行日
1999-06-25
EDB ID
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
病院
薬学系
医学系