| ID | 112327 |
| Author |
Tanigawa, Hiroki
Kumamoto University
Miyata, Keishi
Kumamoto University
Tian, Zhe
Kumamoto University
Aoi, Jun
Kumamoto University
Kadomatsu, Tsuyoshi
Kumamoto University
Fukushima, Satoshi
Kumamoto University
Ogata, Aki
Kumamoto University
Takeda, Naoki
Kumamoto University
Zhao, Jiabin
Kumamoto University
Zhu, Shunshun
Kumamoto University
Terada, Kazutoyo
Kumamoto University
Endo, Motoyoshi
Kumamoto University
Morinaga, Jun
Kumamoto University
Sugizaki, Taichi
Kumamoto University
Sato, Michio
Kumamoto University
Morioka, Masaki Suimye
University of Tokyo
Manabe, Ichiro
University of Tokyo
Mashimo, Youichi
Chiba University
Hata, Akira
Chiba University
Taketomi, Yoshitaka
Tokyo Metropolitan Institute of Medical Science
Yamamoto, Kei
Tokyo Metropolitan Institute of Medical Science|Tokushima University
Tokushima University Educator and Researcher Directory
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Murakami, Makoto
Tokyo Metropolitan Institute of Medical Science
Araki, Kimi
Kumamoto University
Jinnin, Masatoshi
Kumamoto University
Ihn, Hironobu
Kumamoto University
Oike, Yuichi
Kumamoto University
|
| Content Type |
Journal Article
|
| Description | Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evaluate therapeutic strategies. Here, we found that epidermal ANGPTL6 expression was markedly induced during tissue repair in mice. Analysis of mice overexpressing ANGPTL6 in keratinocytes (K14-Angptl6 Tg mice) revealed that epidermal ANGPTL6 activity promotes aberrant epidermal barrier function due to hyperproliferation of prematurely differentiated keratinocytes. Moreover, skin tissues of K14-Angptl6 Tg mice showed aberrantly activated skin tissue inflammation seen in psoriasis. Levels of the proteins S100A9, recently proposed as therapeutic targets for psoriasis, also increased in skin tissue of K14-Angptl6 Tg mice, but psoriasis-like inflammatory phenotypes in those mice were not rescued by S100A9 deletion. This finding suggests that decreasing S100A9 levels may not ameliorate all cases of psoriasis and that diverse mechanisms underlie the condition. Finally, we observed enhanced levels of epidermal ANGPTL6 in tissue specimens from some psoriasis patients. We conclude that the K14-Angptl6 Tg mouse is useful to investigate psoriasis pathogenesis and for preclinical testing of new therapeutics. Our study also suggests that ANGPTL6 activation in keratinocytes enhances psoriasis susceptibility.
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| Journal Title |
Scientific Reports
|
| ISSN | 20452322
|
| Publisher | Springer Nature
|
| Volume | 6
|
| Start Page | 34690
|
| Published Date | 2016-10-04
|
| Remark | Supplementary Information : srep_6_34690_s1.pdf
|
| Rights | © The Author(s) 2016
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Bioscience and Bioindustry
|
