Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis

Tanigawa, Hiroki; Miyata, Keishi; Tian, Zhe; Aoi, Jun; Kadomatsu, Tsuyoshi; Fukushima, Satoshi; Ogata, Aki; Takeda, Naoki; Zhao, Jiabin; Zhu, Shunshun; Terada, Kazutoyo; Endo, Motoyoshi; Morinaga, Jun; Sugizaki, Taichi; Sato, Michio; Morioka, Masaki Suimye; Manabe, Ichiro; Mashimo, Youichi; Hata, Akira; Taketomi, Yoshitaka; Yamamoto, Kei; Murakami, Makoto; Araki, Kimi; Jinnin, Masatoshi; Ihn, Hironobu; Oike, Yuichi

doi:10.1038/srep34690

直近一年間の累計

アクセス数 : ? 件

ダウンロード数 : ? 件

この文献の参照には次のURLをご利用ください : https://repo.lib.tokushima-u.ac.jp/112327

ID	112327
著者	Tanigawa, Hiroki Kumamoto University Miyata, Keishi Kumamoto University Tian, Zhe Kumamoto University Aoi, Jun Kumamoto University Kadomatsu, Tsuyoshi Kumamoto University Fukushima, Satoshi Kumamoto University Ogata, Aki Kumamoto University Takeda, Naoki Kumamoto University Zhao, Jiabin Kumamoto University Zhu, Shunshun Kumamoto University Terada, Kazutoyo Kumamoto University Endo, Motoyoshi Kumamoto University Morinaga, Jun Kumamoto University Sugizaki, Taichi Kumamoto University Sato, Michio Kumamoto University Morioka, Masaki Suimye University of Tokyo Manabe, Ichiro University of Tokyo Mashimo, Youichi Chiba University Hata, Akira Chiba University Taketomi, Yoshitaka Tokyo Metropolitan Institute of Medical Science 山本, 圭 Tokyo Metropolitan Institute of Medical Science\|Tokushima University 徳島大学教育研究者総覧 KAKEN研究者をさがす Murakami, Makoto Tokyo Metropolitan Institute of Medical Science Araki, Kimi Kumamoto University Jinnin, Masatoshi Kumamoto University Ihn, Hironobu Kumamoto University Oike, Yuichi Kumamoto University
資料タイプ	学術雑誌論文
抄録	Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evaluate therapeutic strategies. Here, we found that epidermal ANGPTL6 expression was markedly induced during tissue repair in mice. Analysis of mice overexpressing ANGPTL6 in keratinocytes (K14-Angptl6 Tg mice) revealed that epidermal ANGPTL6 activity promotes aberrant epidermal barrier function due to hyperproliferation of prematurely differentiated keratinocytes. Moreover, skin tissues of K14-Angptl6 Tg mice showed aberrantly activated skin tissue inflammation seen in psoriasis. Levels of the proteins S100A9, recently proposed as therapeutic targets for psoriasis, also increased in skin tissue of K14-Angptl6 Tg mice, but psoriasis-like inflammatory phenotypes in those mice were not rescued by S100A9 deletion. This finding suggests that decreasing S100A9 levels may not ameliorate all cases of psoriasis and that diverse mechanisms underlie the condition. Finally, we observed enhanced levels of epidermal ANGPTL6 in tissue specimens from some psoriasis patients. We conclude that the K14-Angptl6 Tg mouse is useful to investigate psoriasis pathogenesis and for preclinical testing of new therapeutics. Our study also suggests that ANGPTL6 activation in keratinocytes enhances psoriasis susceptibility.
掲載誌名	Scientific Reports
ISSN	20452322
出版者	Springer Nature
巻	6
開始ページ	34690
発行日	2016-10-04
備考	Supplementary Information : srep_6_34690_s1.pdf
権利情報	© The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID	321110
出版社版DOI	10.1038/srep34690
出版社版URL	https://doi.org/10.1038/srep34690
フルテキストファイル	srep_6_34690.pdf 1.42 MB srep_6_34690_s1.pdf 4.48 MB
言語	eng
著者版フラグ	出版社版
部局	生物資源系