ID 112437
Author
Nakagawa-Senda, Hiroko Aichi Cancer Center Research Institute|Nagoya University|Nagoya City University
Hachiya, Tsuyoshi Iwate Medical University
Shimizu, Atsushi Iwate Medical University
Hosono, Satoyo Aichi Cancer Center Research Institute
Oze, Isao Aichi Cancer Center Research Institute
Watanabe, Miki Aichi Cancer Center Research Institute
Matsuo, Keitaro Aichi Cancer Center Research Institute|Nagoya University
Ito, Hidemi Aichi Cancer Center Research Institute|Nagoya University
Hara, Megumi Saga University
Nishida, Yuichiro Saga University
Endoh, Kaori University of Shizuoka
Kuriki, Kiyonori University of Shizuoka
Nindita, Yora Kagoshima University
Ibusuki, Rie Kagoshima University
Suzuki, Sadao Nagoya City University
Hosono, Akihiro Nagoya City University
Mikami, Haruo Chiba Cancer Center
Nakamura, Yohko Chiba Cancer Center
Takashima, Naoyuki Shiga University of Medical Science
Nakamura, Yasuyuki Ryukoku University
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Furusyo, Norihiro Kyushu University
Ikezaki, Hiroaki Kyushu University
Nakatochi, Masahiro Nagoya University
Sasakabe, Tae Nagoya University
Kawai, Sayo Nagoya University
Okada, Rieko Nagoya University
Hishida, Asahi Nagoya University
Naito, Mariko Nagoya University
Wakai, Kenji Nagoya University
Momozawa, Yukihide RIKEN
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center Research Institute
Content Type
Journal Article
Description
Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12–13 and 5q33.3) that met suggestive significance (P < 1 × 10−6). In the replication stage (n = 4,949), the lead variant for the 12q24.12–13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10−6), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10−16 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
8
Start Page
1493
Published Date
2018-01-24
Remark
Supplementary Information : srep_8_1493_s1.pdf
Rights
© The Author(s) 2018
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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language
eng
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departments
Medical Sciences