ID 112458
Title Alternative
8-PN promotes recovery from muscle atrophy via Akt pathway
Author
Horikawa, Hitomi Tokushima University
Lin, Pei-Yi Tokushima University
Tsukumo, Nao Tokushima University
Kawamura, Tomoyuki Tokushima University
Keywords
disuse muscle atrophy
8-prenylnaringenin
IGF1/PI3K/Akt pathway
phosphorylation
nutritional supplement
Content Type
Journal Article
Description
8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiologic concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy.
Journal Title
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
ISSN
03636119
15221490
NCID
AA00521155
Publisher
The American Physiological Society
Volume
311
Issue
6
Start Page
R1022
End Page
R1031
Published Date
2016-12-01
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Bioscience and Bioindustry
Medical Sciences
Pharmaceutical Sciences