ID 112846
Author
Bando, Hiroshi Tokushima University|Low Carbohydrate Diet Promotion Association KAKEN Search Researchers
Ebe, K Low Carbohydrate Diet Promotion Association|Takao Hospital
Bando, M Tokushima University
Yonei, Y Doshisha University
Keywords
C-peptide index for Carbohydrate-70 (CPI-Carbo70)
Insulinogenic index (IGI)
Calorie Restriction (CR)
low carbohydrate diet (LCD)
type 2 diabetes mellitus (T2DM)
Content Type
Journal Article
Description
Background: Authors and colleagues have undertaken clinical research on Carbohydrate (CR) and Low Carbohydrate Diet (LCD) for years. We have proposed new evaluation method of insulinogenic index-carbohydrate 70g (IGI-carbo70). In similar way, C-peptide index for Carbohydrate-70 (CPI-Carbo70) is proposed in this report.
Subjects and methods: The subjects were 37 patients with Type 2 diabetes mellitus (T2DM) and admitted for further evaluation and treatment. CR diet was provided on day 1 and 2, including 60% carbohydrates, 25% lipids and 15% protein with 1400 kcal/day. On day 2, breakfast with 70g of carbohydrate was provided, and glucose and C-peptide values were measured at 0 and 30 minutes.
Results: Average HbA1c was 8.1 %, and Morbus (M) value was 70.5 in median. Glucose and C-peptide on 0--30min significantly increased as 163--195 mg/dL, 1.1--1.5μU/mL, respectively. CPI-Carbo70 was 1.94 in average and 1.54 in median. There were significant correlations between increments of glucose and C-peptide, and between HbA1c and CPI-Carbo70.
Discussion and conclusion: CPI-Carbo70 was investigated and proposed. It may be useful for evaluating the function of the pancreas. This research would give the fundamental data for this field, and further research development will be expected in the future.
Journal Title
Journal of Clinical Investigation and Studies
ISSN
26314002
Publisher
open access text
Volume
1
Issue
1
Start Page
102
Published Date
2018-05-25
Rights
©2018 Bando H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences