Nishida, Kensei Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sawada, D Asahi Group Holdings, Ltd.
Kawai, Tomoko Tokushima University
Kuwano, Yuki Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fujiwara, Shigeru Asahi Group Holdings, Ltd.
Lactobacillus gasseri CP2305
Aims: To confirm the stress-relieving effects of heat-inactivated, entericcolonizing Lactobacillus gasseri CP2305 (paraprobiotic CP2305) in medical students taking a cadaver dissection course.
Methods and Results: Healthy students (21 males and 11 females) took paraprobiotic CP2305 daily for 5 weeks during a cadaver dissection course. The General Health Questionnaire and the Pittsburgh Sleep Quality Index were employed to assess stress-related somatic symptoms and sleep quality respectively. The aggravation of stress-associated somatic symptoms was observed in female students (P = 0･029). Sleep quality was improved in the paraprobiotic CP2305 group (P = 0･038), particularly in men (P = 0･004). Among men, paraprobiotic CP2305 shortened sleep latency (P = 0･035) and increased sleep duration (P = 0･048). Diarrhoea-like symptoms were also effectively controlled with CP2305 (P = 0･005) in men. Thus, we observed sex-related differences in the effects of paraprobiotic CP2305. In addition, CP2305 affected the growth of faecal Bacteroides vulgatus and Dorea longicatena, which are involved in intestinal inflammation.
Conclusions: CP2305 is a potential paraprobiotic that regulates stress responses, and its beneficial effects may depend on specific cell component(s).
Significance and Impact of the Study: This study characterizes the effects of a stress-relieving para-psychobiotic in humans.
Journal of Applied Microbiology
The Society for Applied Microbiology|John Wiley & Sons Ltd
© 2017 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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