ID 112974
Title Alternative
Para-psychobiotic CP2305
Author
Sawada, D Asahi Group Holdings, Ltd.
Kawai, Tomoko Tokushima University
Fujiwara, Shigeru Asahi Group Holdings, Ltd.
Keywords
faecal microbiota
Lactobacillus gasseri CP2305
para-psychobiotics
sleep quality
stress-relieving effects
Content Type
Journal Article
Description
Aims: To confirm the stress-relieving effects of heat-inactivated, entericcolonizing Lactobacillus gasseri CP2305 (paraprobiotic CP2305) in medical students taking a cadaver dissection course.
Methods and Results: Healthy students (21 males and 11 females) took paraprobiotic CP2305 daily for 5 weeks during a cadaver dissection course. The General Health Questionnaire and the Pittsburgh Sleep Quality Index were employed to assess stress-related somatic symptoms and sleep quality respectively. The aggravation of stress-associated somatic symptoms was observed in female students (P = 0・029). Sleep quality was improved in the paraprobiotic CP2305 group (P = 0・038), particularly in men (P = 0・004). Among men, paraprobiotic CP2305 shortened sleep latency (P = 0・035) and increased sleep duration (P = 0・048). Diarrhoea-like symptoms were also effectively controlled with CP2305 (P = 0・005) in men. Thus, we observed sex-related differences in the effects of paraprobiotic CP2305. In addition, CP2305 affected the growth of faecal Bacteroides vulgatus and Dorea longicatena, which are involved in intestinal inflammation.
Conclusions: CP2305 is a potential paraprobiotic that regulates stress responses, and its beneficial effects may depend on specific cell component(s).
Significance and Impact of the Study: This study characterizes the effects of a stress-relieving para-psychobiotic in humans.
Journal Title
Journal of Applied Microbiology
ISSN
13652672
13645072
NCID
AA11115564
Publisher
The Society for Applied Microbiology|John Wiley & Sons Ltd
Volume
123
Issue
6
Start Page
1561
End Page
1570
Published Date
2017-09-26
Rights
© 2017 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences