ID 112974
タイトル別表記
Para-psychobiotic CP2305
著者
Sawada, D Asahi Group Holdings, Ltd.
河合, 智子 Tokushima University
Fujiwara, Shigeru Asahi Group Holdings, Ltd.
キーワード
faecal microbiota
Lactobacillus gasseri CP2305
para-psychobiotics
sleep quality
stress-relieving effects
資料タイプ
学術雑誌論文
抄録
Aims: To confirm the stress-relieving effects of heat-inactivated, entericcolonizing Lactobacillus gasseri CP2305 (paraprobiotic CP2305) in medical students taking a cadaver dissection course.
Methods and Results: Healthy students (21 males and 11 females) took paraprobiotic CP2305 daily for 5 weeks during a cadaver dissection course. The General Health Questionnaire and the Pittsburgh Sleep Quality Index were employed to assess stress-related somatic symptoms and sleep quality respectively. The aggravation of stress-associated somatic symptoms was observed in female students (P = 0・029). Sleep quality was improved in the paraprobiotic CP2305 group (P = 0・038), particularly in men (P = 0・004). Among men, paraprobiotic CP2305 shortened sleep latency (P = 0・035) and increased sleep duration (P = 0・048). Diarrhoea-like symptoms were also effectively controlled with CP2305 (P = 0・005) in men. Thus, we observed sex-related differences in the effects of paraprobiotic CP2305. In addition, CP2305 affected the growth of faecal Bacteroides vulgatus and Dorea longicatena, which are involved in intestinal inflammation.
Conclusions: CP2305 is a potential paraprobiotic that regulates stress responses, and its beneficial effects may depend on specific cell component(s).
Significance and Impact of the Study: This study characterizes the effects of a stress-relieving para-psychobiotic in humans.
掲載誌名
Journal of Applied Microbiology
ISSN
13652672
13645072
cat書誌ID
AA11115564
出版者
The Society for Applied Microbiology|John Wiley & Sons Ltd
123
6
開始ページ
1561
終了ページ
1570
発行日
2017-09-26
権利情報
© 2017 The Authors. Journal of Applied Microbiology published by John Wiley & Sons Ltd on behalf of The Society for Applied Microbiology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
344576
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系