ID 113035
Title Alternative
FMD, PWV, and Cardiovascular Events
Maruhashi, Tatsuya Hiroshima University
Soga, Junko Hiroshima University
Fujimura, Noritaka Hiroshima University
Idei, Naomi Hiroshima University
Mikami, Shinsuke Hiroshima University
Iwamoto, Yumiko Hiroshima University
Iwamoto, Akimichi Hiroshima University
Kajikawa, Masato Hiroshima University
Matsumoto, Takeshi Hiroshima University
Oda, Nozomu Hiroshima University
Kishimoto, Shinji Hiroshima University
Matsui, Shogo Hiroshima University
Hashimoto, Haruki Hiroshima University
Aibara, Yoshiki Hiroshima University
Yusoff, Farina Mohamad Hiroshima University
Hidaka, Takayuki Hiroshima University
Kihara, Yasuki Hiroshima University
Chayama, Kazuaki Hiroshima University
Noma, Kensuke Hiroshima University
Nakashima, Ayumu Hiroshima University
Goto, Chikara Hiroshima International University
Tomiyama, Hirofumi Tokyo Medical University
Takase, Bonpei National Defense Medical College
Kohro, Takahide Tokyo Medical University
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Koba, Shinji Showa University
Watanabe, Kentaro Yamagata University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Ikeda, Hisao Teikyo University
Yamashina, Akira Tokyo Medical University
Higashi, Yukihito Hiroshima University
arterial stiffness
coronary artery disease
endothelial function
flow-induced dilation
pulse wave velocity
Content Type
Journal Article
The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known.
Methods and Results
We measured flow‐mediated vasodilation (FMD) and brachial–ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow‐up period of 49.2 months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients. FMD above the cutoff value of 7.1%, derived from receiver‐operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06–0.74; P=0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09–0.79; P=0.01) primary outcomes. baPWV above the cutoff value of 1731 cm/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01–3.44; P=0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23–3.90; P=0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of FMD and baPWV, stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed.
In patients with coronary artery disease, both FMD and baPWV were significant predictors of cardiovascular events. The combination of FMD and baPWV provided further cardiovascular risk stratification.
Journal Title
Journal of the American Heart Association
The American Heart Association|Wiley
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Published Date
Copyright © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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Medical Sciences