ID 113065
Author
Nishimura-Danjobara, Yumiko KIRARI Dnetal Clinic
Oyama, Keisuke Sakai City Medical Center
Oyama, Tomohiro M. Nishi-Kumamoto Hospital
Keywords
Lymphocytes
3-Oxododecanoyl-homoserine-lactone
Hydrogen peroxide
Zinc
Content Type
Journal Article
Description
N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule, affects intracellular Zn2+ concentration ([Zn2+]i) and cellular levels of nonprotein thiols ([NPT]i) of rat thymic lymphocytes, both of which are assumed to affect cell vulnerability to oxidative stress. Therefore, it is interesting to examine the effects of ODHL on the cells under oxidative stress. ODHL augmented the cytotoxicity of H2O2, but not calcium ionophore A23187. ODHL potentiated the H2O2-induced elevation of [Zn2+]i, wherein, it greatly attenuated the H2O2-induced increase in intracellular Ca2+ concentration. ODHL did not affect [NPT]i in the presence of H2O2. Therefore, we conclude that the elevation of [Zn2+]i is involved in the ODHL-induced potentiation of H2O2 cytotoxicity. Our findings suggest that ODHL modifies cell vulnerability to oxidative stress in host cells.
Journal Title
Chemico-Biological Interactions
ISSN
00092797
NCID
AA0060252X
AA11523855
Publisher
Elsevier
Volume
302
Start Page
143
End Page
148
Published Date
2019-02-16
Remark
論文本文は2020-02-16以降公開予定
Rights
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
language
eng
TextVersion
その他
departments
Bioscience and Bioindustry