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ID 113065
著者
Nishimura-Danjobara, Yumiko KIRARI Dnetal Clinic
Oyama, Keisuke Sakai City Medical Center
Oyama, Tomohiro M. Nishi-Kumamoto Hospital
キーワード
Lymphocytes
3-Oxododecanoyl-homoserine-lactone
Hydrogen peroxide
Zinc
資料タイプ
学術雑誌論文
抄録
N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule, affects intracellular Zn2+ concentration ([Zn2+]i) and cellular levels of nonprotein thiols ([NPT]i) of rat thymic lymphocytes, both of which are assumed to affect cell vulnerability to oxidative stress. Therefore, it is interesting to examine the effects of ODHL on the cells under oxidative stress. ODHL augmented the cytotoxicity of H2O2, but not calcium ionophore A23187. ODHL potentiated the H2O2-induced elevation of [Zn2+]i, wherein, it greatly attenuated the H2O2-induced increase in intracellular Ca2+ concentration. ODHL did not affect [NPT]i in the presence of H2O2. Therefore, we conclude that the elevation of [Zn2+]i is involved in the ODHL-induced potentiation of H2O2 cytotoxicity. Our findings suggest that ODHL modifies cell vulnerability to oxidative stress in host cells.
掲載誌名
Chemico-Biological Interactions
ISSN
00092797
cat書誌ID
AA0060252X
AA11523855
出版者
Elsevier
302
開始ページ
143
終了ページ
148
発行日
2019-02-16
権利情報
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
生物資源系