ID | 113065 |
著者 |
Nishimura-Danjobara, Yumiko
KIRARI Dnetal Clinic
Oyama, Keisuke
Sakai City Medical Center
Oyama, Tomohiro M.
Nishi-Kumamoto Hospital
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キーワード | Lymphocytes
3-Oxododecanoyl-homoserine-lactone
Hydrogen peroxide
Zinc
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資料タイプ |
学術雑誌論文
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抄録 | N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule, affects intracellular Zn2+ concentration ([Zn2+]i) and cellular levels of nonprotein thiols ([NPT]i) of rat thymic lymphocytes, both of which are assumed to affect cell vulnerability to oxidative stress. Therefore, it is interesting to examine the effects of ODHL on the cells under oxidative stress. ODHL augmented the cytotoxicity of H2O2, but not calcium ionophore A23187. ODHL potentiated the H2O2-induced elevation of [Zn2+]i, wherein, it greatly attenuated the H2O2-induced increase in intracellular Ca2+ concentration. ODHL did not affect [NPT]i in the presence of H2O2. Therefore, we conclude that the elevation of [Zn2+]i is involved in the ODHL-induced potentiation of H2O2 cytotoxicity. Our findings suggest that ODHL modifies cell vulnerability to oxidative stress in host cells.
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掲載誌名 |
Chemico-Biological Interactions
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ISSN | 00092797
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cat書誌ID | AA0060252X
AA11523855
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出版者 | Elsevier
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巻 | 302
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開始ページ | 143
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終了ページ | 148
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発行日 | 2019-02-16
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権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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フルテキストファイル | |
言語 |
eng
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著者版フラグ |
著者版
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部局 |
生物資源系
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