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ID 113686
Title Alternative
神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
Author
Afroz, Shaista Tokushima University
Raju, Resmi Tokushima University
Waskitho, Arief Tokushima University
Inoue, Masahisa Tokushima Bunri University
Keywords
Orofacial pain
Neuropathic pain
Sensory ganglia
Glial cell
Cytokine
Chemokine
Content Type
Thesis or Dissertation
Description
Many trigeminal neuropathic pain patients suffer severe chronic pain. The neuropathic pain
might be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the effect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
Journal Title
Neuroscience Letters
ISSN
03043940
NCID
AA11540956
AA00754925
Publisher
Elsevier
Volume
703
Start Page
132
End Page
138
Published Date
2019-03-20
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takuma Iwasaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2019 Elsevier B.V. All rights reserved.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3317号
Diploma Number
甲口第449号
Granted Date
2019-06-13
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences