全身麻酔下の患者の血漿サブスタンスP濃度 : 術後嘔気・嘔吐の有用な指標となる
池﨑, 尚子 Tokushima Univeristy
Kakuta, Nami Tokushima Univeristy Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Horikawa, Yousuke T. Tokushima Univeristy|Sharp Rees-Stealy Medical Group
Tsutsumi, Rie Tokushima Univeristy Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oyama, Takuro Tokushima Univeristy Tokushima University Educator and Researcher Directory
Tanaka, Katsuya Tokushima Univeristy Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Plasma substance P
Thesis or Dissertation
Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15–30 mins prior anesthesia, 15–30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured.
Findings: Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased (P < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery (P = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively).
Conclusions: These finding suggest that SP levels may be utilized as an objective marker for PONV.
JA Clinical Reports
Japanese Society of Anesthesiologists|Springer Nature
© 2016 Kadota et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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k3425_abstract_review.pdf 225 KB
k3425_fulltext.pdf 442 KB
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Doctor of Medical Science