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タイトル別表記
全身麻酔下の患者の血漿サブスタンスP濃度 : 術後嘔気・嘔吐の有用な指標となる
著者
池﨑, 尚子 徳島大学大学院医科学教育部(医学専攻)
Horikawa, Yousuke T. Tokushima Univeristy|Sharp Rees-Stealy Medical Group
キーワード
General anesthesia
Plasma substance P
PONV
Substance P
資料タイプ
学位論文
抄録
Background: This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea and vomiting (PONV). This prospective, observational, cohort study included 23 patients who underwent scheduled surgery under general anesthesia. Blood was collected from the radial artery at predetermined time points (15–30 mins prior anesthesia, 15–30 mins after surgery/GA, and 24 h after surgery). PONV, SP concentrations, risk factors, and analgesics used were measured.
Findings: Nine of 23 patients experienced PONV. In patients without PONV, SP concentrations significantly decreased (P < 0.0001) at the end of surgery/GA, compared to baseline, and recovered at 24 h after surgery/GA (452.9 ± 146.2 vs. 666.9 ± 176.5 vs. 580.7 ± 168.6 pg/mL, respectively), whereas SP levels were unchanged during surgery/GA and increased at 24 hours after surgery (P = 0.020) in patients with PONV (726.1 ± 167.8 vs. 655.8 ± 168.0 vs. 779.7 ± 220.7 pg/mL, respectively).
Conclusions: These finding suggest that SP levels may be utilized as an objective marker for PONV.
掲載誌名
JA Clinical Reports
ISSN
23639024
出版者
Japanese Society of Anesthesiologists|Springer Nature
2
開始ページ
9
発行日
2016-06-02
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Takako Kadotaの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
© 2016 Kadota et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3425号
学位記番号
甲医第1456号
学位授与年月日
2020-04-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院