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ID 115152
Title Alternative
Annual change in bone mineral density in COPD
Goto, Kenichi Shiga University of Medical Science|Takatsuki Red Cross Hospital
Ogawa, Emiko Shiga University of Medical Science
Shimizu, Kaoruko Hokkaido University
Makita, Hironi Hokkaido University
Nishimura, Masaharu Hokkaido University
Nakano, Yasutaka Shiga University of Medical Science
quantitative CT analysis
low attenuation volume
automatic analysis
systemic effect
Content Type
Journal Article
Background: Osteoporosis is a well-known comorbidity in COPD. It is associated with poor health status and prognosis. Although the exact pathomechanisms are unclear, osteoporosis is suggested to be either a comorbidity due to shared risk factors with COPD or a systematic effect of COPD with a cause–effect relationship. This study aimed to evaluate whether progression of osteoporosis is synchronized with that of COPD.
Materials and methods: Data from 103 patients with COPD included in the Hokkaido COPD cohort study were analyzed. Computed tomography (CT) attenuation values of thoracic vertebrae 4, 7, and 10 were measured using custom software, and the average value (average bone density; ABD4,7,10) was calculated. The percentage of low attenuation volume (LAV%) for each patient was also calculated for evaluation of emphysematous lesions. Annual change in thoracic vertebral CT attenuation, which is strongly correlated with dual-energy X-ray absorptiometry-measured bone mineral density, was compared with that in FEV1.0 or emphysematous lesions.
Results: In the first CT data set, ABD4,7,10 was significantly correlated with age (ρ=–0.331; p=0.0006), body mass index (BMI; ρ=0.246; p=0.0136), St George’s Respiratory Questionnaire (SGRQ) activity score (ρ=–0.248; p=0.0115), eosinophil count (ρ=0.229; p=0.0198), and LAV% (ρ=–0.372; p=0.0001). However, ABD4,7,10 was not associated with FEV1.0. After adjustment for age, BMI, SGRQ activity score, and eosinophil count, no significant relationship was found between ABD4,7,10 and LAV%. Annual change in ABD4,7,10 was not associated with annual change in LAV% or FEV1.0.
Conclusion: Progression of osteoporosis and that of COPD are not directly related or synchronized with each other.
Journal Title
International Journal of Chronic Obstructive Pulmonary Disease
Dove Medical Press
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Science and Technology