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ID 115369
Author
Majima, Dai Tokushima University
Mitsuhashi, Ryosuke Tokushima University
Yamasaki, Misaki Tokushima University
Kajimoto, Kazuaki The National Institute of Advanced Industrial Science and Technology
Keywords
tocopheryl succinate
adipocyte
lipolysis
anti-obesity
Content Type
Journal Article
Description
Obesity is a pathological state related to various lifestyle-related diseases, such as diabetes and dyslipidemia, that may be prevented through the development of anti-obesity treatments. Lipid accumulation in cells could be affected by vitamin E ester α-tocopheryl succinate (TS), which has various biological activities, such as anti-cancer effect, via activation of cell signaling pathways, although the antioxidative activity of TS is lost due to esterification of the phenolic OH group. In this study, we found for the first time that TS significantly suppressed lipid accumulation in mouse 3T3-L1 adipocytes. TS treatment reduced the amount of triglycerides in the culture medium, and inhibited activity of glycerol-3-phosphate dehydrogenase, a marker of lipid synthesis. Furthermore, TS accelerated lipolysis. Treatment of adipocytes with TS for 24 h induced no significant cytotoxicity. In TS-treated cells, phosphorylation of Akt, which is involved in fatty acid synthesis via sterol regulatory element-binding proteins (SREBP), was prevented, while levels of phosphorylated protein kinase A (PKA) did not change. Taken together, these results suggest that vitamin E ester TS can suppress lipid accumulation in adipocytes by regulating lipid metabolic cell signaling.
Journal Title
Biological and Pharmaceutical Bulletin
ISSN
09186158
13475215
NCID
AA10885497
AA11696048
Publisher
The Pharmaceutical Society of Japan
Volume
44
Issue
1
Start Page
46
End Page
50
Published Date
2021-01-01
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences